Margarita

Margarita is a Hardmode potion that is sold by the Drunk Princess NPC after defeating Plantera. It grants the Margarita debuff when consumed, which reduces life regen and defense, but halves the duration to most debuffs. It also heals the player for 200 life and mana. It also inflicts the Potion Sickness debuff for 1 minute and the Mana Sickness debuff for 5 seconds.

While the effects of the Margarita debuff are mostly beneficial, it is still considered a debuff, and therefore cannot be removed by right-clicking the icon.