Screwdriver

Screwdriver is a Hardmode potion that is sold by the Drunk Princess NPC after all the Mechanical Bosses have been defeated. It grants the Screwdriver debuff when consumed, which reduces life regen, but boosts the damage of piercing projectiles.

While the effects of the Screwdriver debuff are mostly beneficial, it is still considered a debuff, and therefore cannot be removed by right-clicking the icon.