Tequila

Tequila is a Hardmode potion that is sold by the Drunk Princess NPC. It grants the Tequila debuff when consumed, which reduces life regen, but boosts damage, critical strike chance, knockback, defense and damage reduction during the day.

While the effects of the Tequila debuff are mostly beneficial, it is still considered a debuff, and therefore cannot be removed by right-clicking the icon.