Everclear

Everclear is a Hardmode potion that is sold by the Drunk Princess NPC after Astrum Aureus has been defeated. It grants the Everclear debuff when consumed, which reduces life regen and defense, but boosts damage by 25%.

While the effects of the Everclear debuff are mostly beneficial, it is still considered a debuff, and therefore cannot be removed by right-clicking the icon.

Trivia

 * The real-life Everclear has anywhere from 60% to 95% alcohol content, unlike most drinks which have around 30%.