Vodka

Vodka is a Hardmode potion that is sold by the Drunk Princess NPC after all the Mechanical Bosses have been defeated. It grants the Vodka debuff when consumed, which reduces life regen and defense, but boosts damage and critical strike chance.

While the effects of the Vodka debuff are mostly beneficial, it is still considered a debuff, and therefore cannot be removed by right-clicking the icon.