Blood Orbs are a crafting material dropped by enemies during a Blood Moon. They can be used to create any vanilla or Calamity buff potions as well as upgrade Supreme Healing Potions into Omega Healing Potions, and craft Bloodstone Cores. Wearing Bloodflare armor or Auric Tesla armor increases the chance of enemies dropping Blood Orbs.
- All Potions crafted with Blood Orbs can only be crafted at an Alchemy Table except the Omega Healing Potion and Calamitas' Brew, which require Draedon's Forge and the Imbuing Station respectively.
- Xerocodiles also provide 5-15 Blood Orbs when opened.
- Blood Orbs will not be dropped from enemies spawned by Statues.