Permanent Power-ups

Main article: Potion

Health Upgrades
Item	Ingredients	Effect	Hearts
Blood Orange	Soul of Sight (5) Soul of Might (5) Soul of Fright (5) Orange Bloodroot Blood Orb (10) Life Fruit (5)	Permanently increases maximum life by 25
Miracle Fruit	Life Fruit (5) Teal Mushroom Trapper Bulb (5) Living Shard (10) Life Alloy (5)	Permanently increases maximum life by 25
Elderberry	Blue Berries Divine Geode (10) Life Fruit (5) Uelibloom Bar (10) Unholy Essence (20)	Permanently increases maximum life by 25
Dragonfruit	Life Fruit (5) Sky Blue Flower Solar Fragment (15) Yharon Soul Fragment (2) Ascendant Spirit Essence	Permanently increases maximum life by 25
Mana Upgrades
Item	Ingredients	Effect	Stars
Enchanted Starfish	10% chance to be fished up in the Surface at night	Permanently increases maximum mana by 20. (Multiple can be used, until the limit of 200 mana has been reached, the same as Mana Crystals)
Comet Shard	Meteorite Bar (10) Fallen Star (50) Stardust (150)	Permanently increases maximum mana by 50
Ethereal Core	Meteorite Bar (25) Astral Bar (25) Nebula Fragment (20) Fallen Star (50)	Permanently increases maximum mana by 50
Phantom Heart	Phantoplasm (100) Ruinous Soul (10)	Permanently increases maximum mana by 50

Rage Mode Upgrades
Item	Drops from	Effect
Mushroom Plasma Root	Crabulon	Permanently increases the Rage Mode duration by one second. Exclusive to Revengeance Mode and Death Mode.
Infernal Blood	Ravager	Permanently increases the Rage Mode duration by one second. Exclusive to Revengeance Mode and Death Mode.
Red Lightning Container	The Dragonfolly	Permanently increases the Rage Mode duration by one second. Exclusive to Revengeance Mode and Death Mode.
Adrenaline Mode Upgrades
Item	Drops from	Effect
Electrolyte Gel Pack	The Slime God	Permanently increases Adrenaline Mode damage by 15% and damage reduction by 5%. Exclusive to Revengeance Mode and Death Mode.
Starlight Fuel Cell	Astrum Aureus	Permanently increases Adrenaline Mode damage by 15% and damage reduction by 5%. Exclusive to Revengeance Mode and Death Mode.
Ectoheart	Polterghast	Permanently increases Adrenaline Mode damage by 15% and damage reduction by 5%. Exclusive to Revengeance Mode and Death Mode.

Other Upgrades
Item	Drops from	Effect
Demon Trophy	Wall of Flesh	Permanently boosts enemy spawn rates in the current world by 25%.
Hermit's Box of One Hundred Medicines	Wall of Flesh	Permanently makes the player respawn with full health. Non-consumable. Can be toggled.
Celestial Onion	Moon Lord	Permanently adds a sixth / seventh accessory slot.