Calamity Mod Wiki
Type Debuff
Effects No health regeneration
-10 health per second, -4 defense, -15% move speed, and darkness debuff is inflicted. (if player)
-50 health per second and -4 defense. (if enemy)
Tooltip Rotting from the inside
If you were looking for something other than the Plague debuff, see Plague (disambiguation).

Plague is a debuff inflicted primarily by "plagued" enemies in the Jungle as well as weapons dropped by The Plaguebringer Goliath. It causes the target to lose 50 health per second and 4 defense as well as emitting large, green particles. When inflicted on a player, the player loses 10 health per second, 4 defense, and 15% movement speed. Additionally, vision is reduced similarly to the Darkness debuff, and the player emits large, green particles.

When the player has Alchemical Flask, Plaguebringer Carapace, Plague Hive, or Plague Reaper Vest equipped, they lose 5 health per second instead. Additionally, the Alchemical Flask and Plague Hive cancel out the vision loss effect too.


From player[]

In addition to the causes listed below, items that inflict Elemental Mix will inflict Plague as a part of that.

From Duration Chance
Acid Round Acid Round 6 seconds 100%
Alchemical Flask Alchemical Flask 2, 4, or 6 seconds (On attack)
5 seconds (Plague seekers)
Alpha Virus Alpha Virus 2 seconds (plague cell)
3 seconds (plague seeker)
Ark of the Cosmos Ark of the Cosmos 20 seconds 100% (Stars when in the Jungle)
Blight Spewer Blight Spewer 5 seconds 100%
Contagion Contagion 10 seconds (Arrow, Explosion)
6 seconds (Orb)
Diseased Pike Diseased Pike 6 seconds 100%
Elemental Eruption Elemental Eruption 2 seconds 100%
Epidemic Shredder Epidemic Shredder 5 seconds (Boomerang)
3 seconds (Plague seekers)
Fuel Cell Bundle Fuel Cell Bundle 3 seconds 100%
Galaxia Galaxia 20 seconds 100% (When in the Jungle)
Infected Remote Infected Remote 3 seconds (Contact)
2 seconds (Missile, Mini-Plaguebringer)
1 second (Plague Bee)
Malevolence Malevolence 10 seconds 100%
Omega Biome Blade Omega Biome Blade 10 seconds 100% (When in the Jungle)
Pandemic Pandemic 10 seconds (Yoyo)
5 seconds (Plague seekers)
Pestilent Defiler Pestilent Defiler 6 seconds (Main shot)
3 seconds (Split shots)
Plague Hive Plague Hive 2, 4, or 6 seconds (On attack)
6 seconds (Bee/wasp projectiles)
5 seconds (Plague Seekers)
Plague Keeper Plague Keeper 5 seconds (Contact)
3 seconds (Dust)
Plague Reaper armor Plague Reaper armor 2 seconds (Plague Cinders) 100%
Plague Staff Plague Staff 5 seconds 100%
Plagued Fuel Pack Plagued Fuel Pack 5 seconds 100%
Plaguenade Plaguenade 5 seconds (Plague bees)
10 seconds (Plaguenade)
Soul Harvester Soul Harvester 5 seconds 100%
Tactical Plague Engine Tactical Plague Engine 3 seconds (Missile) 100%
The Hive The Hive 5 seconds 75%
The Syringe The Syringe 10 seconds (Syringe)
2 seconds (Glass and Cinders)
5 seconds (Bees)
Toxic Heart Toxic Heart 2 seconds (Aura) 100%
True Biome Blade True Biome Blade 6 seconds 100% (When in the Jungle)
Virulence Virulence 4 seconds 100%
Wither Blossoms Staff Wither Blossoms Staff 3 seconds 100%

From NPCs[]

From Duration Chance
The Plaguebringer Goliath The Plaguebringer Goliath 4 seconds (Contact)
4 seconds (Plague Stinger explosions)
3 seconds (Plague Missiles)
Plague Homing Missile Plague Homing Missile 3 seconds 100%
Plague Charger Plague Charger 2 seconds 100%
Plague Charger Plague Charger (Small Summon) 2 seconds 100%
Plague Charger Plague Charger (Large Summon) 2 seconds 100%
Plaguebringer Plaguebringer 2 seconds (Contact)
5 seconds (Plague rocket)
4 seconds (Stinger explosion)
Viruling Viruling 3 seconds 100%
Pestilent Slime Pestilent Slime 3 seconds 100%
Melter Melter 3 seconds 100%
Plagueshell Plagueshell 3 seconds 100%

Immune NPCs[]

  • Trivia[]